Video Article Open Access
Nucleic Acid Based Biomaterials from Supramolecular Systems to Therapeutic Applications
1University of Bordeaux, ARNA laboratory, F-33000 Bordeaux, France
2INSERM, U1212, ARNA Laboratory
3UMR CNRS 5320
Vid. Proc. Adv. Mater., Volume 3, Article ID 2208305 (2022)
Publication Date (Web): 27 Nov 2022
Copyright © IAAM
Amphiphilic biomolecules are emerging as promising supramolecular materials for biomedical and technological applications. In this presentation we will highlight the recent progresses in the field of nucleic acid-based lipids with an emphasis on their molecular design, supramolecular properties, physicochemical behaviors, and applications in the field of health science. In a first part we will focus on the design and the study of nucleolipids and the glyconucleolipid family. Also, recent contributions of responsive materials involving nucleolipids and their use as smart drug delivery systems will be discussed. The supramolecular materials generated by nucleic acid-based lipids open new challenges for biomedical applications,  including the fields of medicinal chemistry, biosensors, biomaterials for tissue engineering, drug delivery, and the decontamination.
Kassahun, G. S., Farias, E. D., Benizri, S., Mortier, C., Gaubert, A., Salinas, G., Garrigue, P., Kuhn, A., Zigah, D., Barthélémy P.; ACS Applied Materials & Interfaces, 2022, 14(23), 26350-26358, DOI: 10.1021/acsami.2c02993
Benizri, S., Gaubert, A. Soulard, C., Gontier, E., Svhan, I., Rocchi, P., Vacher, G., and Barthélémy, P.; Biomaterials Science, 2021. https://doi.org/10.1039/D1BM00273B.
Bansode, N.D., Sindhu, K.R., Morel, C., Murielle, R., Verget, J., Boiziau, C., and Barthélémy P.; A Disulfide Based Low Molecular Weight Gel for a Selective Sustained Release of Biomolecules. Biomaterials Science, 2020, DOI: 10.1039/D0BM00508H.
Baillet, J., Desvergnes, V., Hamoud, A., Latxague, L., Barthélémy, P.; Lipid and Nucleic Acid Chemistries: Combining the Best of Both Worlds to Construct Advanced Biomaterials, Adv. Mater., 2018, 1705078. DOI: 10.1002/adma.201705078.
V. Brune, A. Gissot, R. Delzor and P. Barthelemy, “Controlling G-Quadruplex Formation via Lipid Modification of Oligonucleotide Sequences” Chem. Commun., 2017, DOI: 10.1039/C7CC05693A. c) Ramin MA, Latxague L, Sindhu KR, Chassande O, Barthélémy P, Biomaterials, 2017, “Low Molecular Weight Hydrogels Derived from urea Based- Bolaamphiphiles as New Injectable Biomaterials”. DOI: 10.1016/j.biomaterials.2017.08.034.
M. A. Ramin, K. R. Sindhu, A. Appavoo, K. Oumzil, M. W. Grinstaff, O. Chassande, P. Barthélémy, “Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery” Adv. Mater., 2017, DOI: 10.1002/adma.201605227.
S. Karakia, S. Benizrie, R. Mejíasa, V. Baylota, N. Branger, T. Nguyen, B. Vialet, K. Oumzil, P. Barthélémy, P. Rocchi; “Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer”, Journal of Controlled Release, 2017, 258, 1-9.